Transmucosal delivery of melatonin for prevention of migraine

Details Transmucosal delivery of melatonin for prevention of migraine Transmucosal delivery of melatonin for prevention of migraine

1995-05-24

1997-11-18

Azpuru, Carlos A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424435, 5147726, A61K 4732

Patent

active

056885202

ABSTRACT:
A method of reducing the frequency of and/or preventing migraine, involving the step of administering melatonin, preferably to and across a mucosal surface, in an amount and for a time sufficient to increase the period of time between episodes of migraine.

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SCRIP, "Migraine--Current Trends in Research and Treatment," May 1990, PJB Publications.
Mallo (Charles Mallo, Thesis, 26 Jan. 1988, L'universite Claude Bernard-Lyon I).
"Plasma Melatonin (M) and Sulfatoxymelatonin (aMT6s) Kinetics After Transmucosal Administration to Humans," 1993, Elsevier Science Publishers B.V. (Benes et al.).

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