Transmucosal delivery of macromolecular drugs

Details Transmucosal delivery of macromolecular drugs Transmucosal delivery of macromolecular drugs

1994-05-16

1996-05-14

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424434, 514953, A61F 1302

Patent

active

055165230

ABSTRACT:
A method and system for mucosally administering a macromolecular drug to mucosa of the oral cavity is shown. The system comprises an inner drug/enhancer/polymer layer having one surface adapted to contact and adhere to the mucosal tissue of the oral cavity and an opposing surface in contact with and adhering to an overlying inert layer. The inner layer contains from about two to sixty percent by weight of a bile salt enhancer, five to sixty five percent by weight of a hydrophilic polymer which is water soluble or swellable and an effective amount of a macromolecular drug having a molecular weight of at least 500 daltons. Polysaccharides, polypeptides and proteins are preferred forms of macromolecular drugs. The bile salt enhancer facilitates the delivery of macromolecules such as low molecular weight heparin and calcitonin. The polymer serves as a plasticizer to prevent the crystallization and/or aggregation of such macromolecular drugs. Hydroxypropyl cellulose is a particularly suitable polymer.

REFERENCES:
patent: 4772470 (1988-09-01), Inoue et al.
patent: 4994439 (1991-02-01), Longenecker
patent: 5204108 (1993-04-01), Illum
patent: 5346701 (1994-09-01), Heiber et al.

Affiliated with

Also associated with

Rating

Transmucosal delivery of macromolecular drugs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transmucosal delivery of macromolecular drugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transmucosal delivery of macromolecular drugs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1894186