Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1994-12-29
1998-12-29
Sidberry, Hazel F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
4241841, 4241851, 4242721, 530350, 435 691, 435 693, 435 699, 435 711, 435255, A61K 39015, C12N 1500, C12N 700, C12P 2102
Patent
active
058537392
ABSTRACT:
The present invention relates to transmission-blocking vaccines against malaria. Vaccines of the present invention contain a recombinant Pfs25 Plasmodium falciparum protein produced by yeast cells and to yeast cells producing the protein. Mice and monkeys inoculated with the yeast-expressed Pfs25 of the present invention have developed antibodies with transmission-blocking activity. The present invention also relates to methods of preventing or treating malarial infections using the vaccines of the present invention.
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Barr Philip J.
Kaslow David C.
Chiron Corporation
Sidberry Hazel F.
The United States of America as represented by the Department of
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