Transmissible spongiform encephalopathy test reagents and...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C424S078350, C435S007800, C436S086000, C514S059000, C536S051000

Reexamination Certificate

active

07659079

ABSTRACT:
The invention provides improved methods and compositions for selectively binding and/or detecting an aggregating abnormal form of a protein in the presence of non-aggregating normal form of the protein.

REFERENCES:
patent: 9830909 (1998-07-01), None
patent: 9941280 (1999-08-01), None
patent: 03/073106 (2003-04-01), None
Pergami et al.Biochem. Biophys. Res. Comm., vol. 264, pp. 972-978, 1999.
Irvine et al, Molecular Med., vol. 14, 2008, pp. 451-464.
Serban, et al., “Rapid detection of Creutzfeldt-Jakob disease and scrapie prion proteins”,Neurology, 40, p. 110-117, (1990).
Brimacombe, et al., “Characterization and polyanion-binding properties of purified recombinant prion protein”, Biochem J., (1999) 342, 605-613.
Notification of International Search Report dated Nov. 18, 2005 for corresponding PCT application International application No. PCT/US2005/011826.

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