Transmetalations from zirconium to copper intermediates

Details Transmetalations from zirconium to copper intermediates Transmetalations from zirconium to copper intermediates

1991-08-20

1992-11-24

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556113, 556 53, 549356, 549429, C07F 108

Patent

active

051663821

ABSTRACT:
Higher order cuprate complexes are prepared by means of a transmetalation from a corresponding zirconate intermediate. This process is particularly valuable with respect to the preparation of vinylic side chains such as are present in prostaglandins, as it is possible in accordance with the present invention to proceed directly from the acetylenic precursors via the reactive cuprates to the desired final products in a one-pot operation without isolation of intermediates and in high yields. Sequential additions to zirconium intermediates of components which together comprise the cuprate involved in transmetalation with the zirconium intermediate are disclosed as alternative procedures.

REFERENCES:
patent: 4777275 (1988-10-01), Campbell et al.
patent: 4785124 (1988-11-01), Campbell et al.
Kluge et al., J. Amer. Chem. Soc., vol. 94, No. 22, pp. 7827-7832 (1972).

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