Transmembrane serine protease overexpressed in ovarian...

Details Transmembrane serine protease overexpressed in ovarian... Transmembrane serine protease overexpressed in ovarian...

2007-09-04

2007-09-04

Helms, Larry R. (Department: 1643)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023200, C530S300000, C530S387100, C435S071100, C435S320100, C435S325000

Reexamination Certificate

active

10357175

ABSTRACT:
The present invention provides a transmembrane serine protease TADG-12 protein, splice variants of the TADG-12 protein and DNA fragments encoding such proteins. Also provided are vectors and host cells capable of expressing the DNAs. The present invention further provides various methods of early detection and therapies of associated ovarian and other malignancies by utilizing the DNAs and/or proteins disclosed herein.

REFERENCES:
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Bonne-Tamir et al., Am. J. Hum. Genet. 58(6): 1254-1259; 1996.
GenBank Acessin No. NM—024022.
GenBank Acession No. AB038160.
Burgess et al, Journal of Cell Biology vol. 111 Nov. 1990 2129-2138.
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Lin et al Biochemistry USA vol. 14:1559-1563 (1975).
Paoloni-Giacobino et al (Genomics 44, 309-320; 1997).

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