Translational activity-promoting higher-order structure

Details Translational activity-promoting higher-order structure Translational activity-promoting higher-order structure

2006-11-21

2006-11-21

Kam, Chih-Min (Department: 1656)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S005000, C435S325000, C435S320100, C435S456000

Reexamination Certificate

active

07138515

ABSTRACT:
The present invention was conceived from the findings; that a specific higher-order structure can be formed in CrP-like viruses; that linkage of a gene reading frame downstream in the higher-order structure permits initiating the translation of a protein from various amino acids; and that a change in the combination of base pairs involved in the formation of the higher-order structure immediately upstream in the translation initiation site permits initiating the synthesis of any protein from any codon.

REFERENCES:
Sasaki et al., J. Virology, 73, 1219-1226, (Feb. 1999).
Sasaki et al., PNAS 97, No. 4, 1512-1515 (Feb. 2000).

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