Translation enhancer

Details Translation enhancer Translation enhancer

1987-10-15

1990-06-26

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 681, 435 701, 435 703, 4351721, 4351723, 435 91, 935 4, 935 6, 935 32, 935 33, 935 34, C12P 2100, C12P 1934, C12N 1500

Patent

active

049371908

ABSTRACT:
Disclosed in this patent are DNA sequences, RNA sequences, vectors, and hosts that incorporate a translation enhancer region derived from the 5' non-coding region of a cardiovirus. The enhancer acts at the RNA level (as opposed to the DNA level) to enhance production of proteins in cell free media. Proteinaceous material which is produced will not have attached to it any undesired material from the enhancer sequence. The invention is especially useful to enable efficient production of selected viral proteins of picornoviruses.

REFERENCES:
Semler et al., (1986), PNAS 83:1777-1781.
G. Parks et al., 60 J. Virol., 376-384, (Oct. 17, 1986) (not prior art).
H. Krausslich et al., 61 J. Virol., 2711-2718, (1987) (not prior art).
G. Parks et al., 61 J. Virol. (in press) (Dec. 1987).
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A. Palmenberg et al., 12 Nucl. Acid. Res., 2969-2985, (1984).
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G. Parks et al., "In Vitro Proteolytic Processing of EMC Clones", Jun. 22-26, 1986, American Society For Virology Annual Meeting, University of California, Santa Barbara, Calif., (title only).
G. Duke et al., "Transcription and Translation of EMC cDNA Clones In Vitro", Jun. 22-26, 1986, American Society For Virology Annual Meeting, University of California, Santa Barabara, Calif., (title only).

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