Transition-state inhibitors for nucleoside hydrolase and transfe

Details Transition-state inhibitors for nucleoside hydrolase and transfe Transition-state inhibitors for nucleoside hydrolase and transfe

1998-02-02

2000-09-19

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 81, 514 89, 514 94, 514256, 514258, 514397, 514424, 514425, 4241571, 4241581, 4241691, 4241701, 4242361, 4242411, 4242571, 4242601, 4242651, 544235, 544243, 544244, 544262, 544335, 546 22, 5462784, 5462787, 5483147, 548413, A61K 3140, C07D20708

Patent

active

061212962

ABSTRACT:
This invention is directed to transition-state analog compounds and to the use of said compounds as inhibitors of nucleoside hydrolase and transferase enzyme activity of parasites. This invention is further directed to the use of said compounds to treat infections and diseases caused by certain bacterial and plant toxins.

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Furneaux, et al., Synthesis of Transition State Inhibitors for N-Riboside Hydrolases and Transferases, 1997, 53(8); 2915-2930.

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