Transition metal-catalyzed process for preparing N-aryl amine co

Details Transition metal-catalyzed process for preparing N-aryl amine co Transition metal-catalyzed process for preparing N-aryl amine co

1999-06-30

2000-08-08

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

548400, 5483001, 548469, 5483601, 548440, 5483561, 564386, 564395, 564405, 560 24, 558418, C07C20910, C07C47300

Patent

active

061003980

ABSTRACT:
Disclosed is a process for the preparation of N-aryl amine compounds, comprising reacting an amine compound with an arylating compound in the presence of a base and a transition metal catalyst under reaction conditions effective to form an N-aryl amine compound, the transition metal catalyst comprising a Group 8 metal and P(t-Bu).sub.3 as a ligand, and wherein the ratio of the ligand to the Group 8 metal is in the range of about 3:1 to about 0.25:1, and wherein the reaction temperature is less than 100.degree. C. The process of the present invention provides a useful general method of N-arylation for the manufacture of pharmaceuticals, polymers, and the like.

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