Transient receptor potential channel TRPV3 and its use

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C514S012200

Reexamination Certificate

active

07396910

ABSTRACT:
This invention provides novel genes and polypeptides of the transient receptor potential channel family, and use of these genes and polypeptides for the treatment of pain and identification of agents useful in the treatment of pain.

REFERENCES:
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patent: 2003/0027232 (2003-02-01), Davis et al.
patent: 2003/0219806 (2003-11-01), Glucksmann et al.
patent: 0 943 683 (1999-09-01), None
patent: WO 01/53348 (2001-07-01), None
NCBI Sequence Viewer, Definition:Homo sapiensVanilloid Receptor-like Protein-1 (VRL-1) mRNA, complete cds, Version AF129112.1 GI:4589140 (Apr. 20, 1999).
NCBI Sequence Viewer, Definition:Rattus norvegicusVanilloid Receptor Subtype 1 mRNA, complete cds, Version AF029310.1 GI:2570932 (Oct. 30, 1997).
NCBI Sequence Viewer, Definition:Homo sapiensOTRPC4 mRNA, complete cds, Version AF258465.1 GI:10304080 (Sep. 26, 2000).
NCBI Sequence Viewer, Definition:Homo sapiensSimilar to Vanilloid Receptor-Related Osmotically Activated Channel Protein (LOC162514), mRNA, Version XM—091604.1 GI:18587705 (Feb. 7, 2002).
NCBI Sequence Viewer, Definition: OTRPC4 Cation Channel, complete cds, Version AAG17543 GI:10443637 (Oct. 2, 2000).
NCBI Sequence Viewer, Definition:Mus musculus, Version Accession No. AF208026.1 GI:10443636 (Oct. 2, 2000).
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Peng et al., “Structural Conservation of the Genes Encoding CaT1, CaT2 and Related Cation Channels”, Genomics, vol. 76, No. 1-3, pp. 99-109 (2001).
Peier et al, “A Heat Sensitive TRP Channel Expressed in Keratinocytes”, Science, vol. 296, No. 5575, pp. 2046-2049, (2002) and Database Accession Nos. NM-145068 XP002239517 & NM—145099 XP002239518 (abstract).
Peng et al., “Structural Conversation of the Genes Encoding CaT1, CaT2, and Related Cation Channels”, Genomics, vol. 76, Nos. 1-3, pp. 99-109 (2001).
Smith et al., “TRPV3 is a Temperature-Sensitive Vanilloid Receptor-Like Protein”, Nature, vol. 418, No. 6894, pp. 186-190, (2002).
Strotmann et al., “OTRPC4, a Nonselective Cation Channel that Confers Sensitivity to Extracellular Osmolarity”, Nat. Cell Biol., vol. 2, pp. 695-702 (2000).
Tsavaler et al., “Trp-p8, a Novel Prostate-Specific Gene, is Up-Regulated in Prostate Cancer and Other Malignancies and Shared High Homology with Transient Receptor Potential Calcium Channel Proteins”, Cancer Res., vol. 61, pp. 3760-3769 (2001).
Peng et al., “Structural Conservation of the Genes Encoding CaT1, CaT2, and Related Cation Channels”, Genomics, vol. 76, Nos. 1-3, pp. 99-109 (2001).
Xu et al., “TRPV3 is a Calcium-Permeable Temperature-Sensitive Cation Channel”, Nature, vol. 418, No. 6894, pp. 181-186, (2002).

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