Transglycosilation process for producing acyclic nucleosides

Details Transglycosilation process for producing acyclic nucleosides Transglycosilation process for producing acyclic nucleosides

1992-07-23

1994-08-09

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544277, C07D47318, C07B 4304

Patent

active

053367707

ABSTRACT:
Herein is disclosed a novel and industrially advantageous process for synthesizing acyclic nucleosides such as acyclovir and ganciclovir from ribonucleosides, which process comprises adding an acid catalyst and an acid anhydride to a solution of a ribonucleoside such as guanosine and an ester derivative of an acyclic sugar, and heating the mixture, whereby a transglycosilation reaction takes place between the ribose moiety of the ribonucleoside and the ester derivative of the acyclic sugar.

REFERENCES:
patent: 4199574 (1980-04-01), Schaeffer
patent: 4835104 (1989-05-01), Yokozeki et al.
Nucleosides and Nucleotides, vol. 6, Nos. 1 and 2, 1987, pp. 385-386, J. Boryski, et al., "Transglycosylation of Guanine Nucleosides".
Nucleosides & Nucleotides, vol. 8, No. 4, 1989, pp. 529-536, J. Boryski, et al., "Application of the Transpurination Reaction to Synthesis of Acyclic Guanosine Analogues".
Database WPIL, Derwent Publications Ltd., AN 86-012206, SU-A-961 354, Aug. 7, 1985.

Affiliated with

Also associated with

Rating

Transglycosilation process for producing acyclic nucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transglycosilation process for producing acyclic nucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transglycosilation process for producing acyclic nucleosides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-216860