Transglutaminases as immunosuppressants

Details Transglutaminases as immunosuppressants Transglutaminases as immunosuppressants

1995-06-06

1997-12-09

Guzo, David

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

514 2, 514 21, 514885, 424 9464, 530381, 530384, A61K 3848, A61K 3855

Patent

active

056957530

ABSTRACT:
A description is given of the possibility of using transglutaminases in a process for the preparation of an immunosuppressant. Additionally described is a pharmaceutical containing a transglutaminase and a plasminogen activator inhibitor.

REFERENCES:
patent: 4327086 (1982-04-01), Fukushima et al.
patent: 4414976 (1983-11-01), Schwarz et al.
patent: 5013719 (1991-05-01), Bowlin
patent: 5464615 (1995-11-01), Stief et al.
Goeken et al., Monocyte Suppressor Factor is Plasminogen Activator Inhibitor; Inhibition of Membrane Bound but not Soluble IL-1, J. of Immuno., 603-608, Jul. 15, 1989.
Astedt et al., The Placental Type Plasminogen Activator Inhibitor, PAI 2, Fibrinolysis, 203-208, 1987.
G. Dickneite, et al. "The Immunosuppressive Properties of 15-Deoxysperqualin and Its Effects on Experimental Skin and Islet Cell Transplantation," Recent Advances in Chemotherapy, Anticancer Section 2, Proceedings of the 14th International Congress of Chemotherapy, Kyoto, pp. 949-950 1985.
"Report of the Meeting of the Subcomittee on Fibrinolysis, Jerusalem, Israel;, Jun. 2, 1986," Thromb. Haem., 56, 415-416.
Suzuki et al., Thrombosis and Haemostasis, vol. 58(1), Jul. 1987, Abstract 509.

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