Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2006-05-30
2006-05-30
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S069100, C435S320100, C435S325000, C435S091210, C530S388260, C536S024330, C536S023200
Reexamination Certificate
active
07052890
ABSTRACT:
The invention provides a nucleotide sequence comprising at least a portion of the nucleotide sequence of FIG.10A, FIG.6B or FIG.10A or FIG.10B; nucleotides which hybridise to the nucleotide sequences of FIG.6A, FIG.6B or FIG.10A or FIG.10B; nucleotides which are degenerate to the nucleotide sequences of FIG.6A, FIG.6B or FIG.10A or FIG.10B; all of which nucleotides encode a polypeptide having transglutaminase activity.
REFERENCES:
patent: 5470957 (1995-11-01), Reed
patent: WO 99/10507 (1999-03-01), None
Kim et al. The deduced sequence of novel protransglutaminase E (TGase3) of human and mouse 1993. Journal of biological chemistry, vol. 268, No. 17pp. 12682-12690.
Szondy et al. Differntial expression of tissue transglutaminaseduring in vivo apoptosis of thymocyte induced via distinct signalling pathways1997. FEBS Letteres 404 307-313.
Lock et al., IgA anti-tissue transglutaminase as a diagnostic marker of gluten sensitive enteropathy 1999. Journal of clinical pathology; 52:274-277.
WO200259265-A2 Gurney M. et. al. (U.S. Appl. No. 60/257,754).
Aeschliemann et al: “Isolation of a cDNA Encoding a Novel Member of the Transglutaminase Gene Family From Human Keratinocytes” Journal of Biological Chemists, Baltimore, MD, US, vol. 273, No. 6, Feb. 6, 1998, pp. 3452-3460, XP002089593, ISSN: 0021-9258, cited in the application figure 3.
Aeschlimann Daniel Peter
Grenard Pascale Marie
Banner & Witcoff LLP
Gebreyesus Kagnew
Prouty Rebecca E.
University College Cardiff Consultants Ltd.
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