Transglutaminase cross-linkable polypeptides and methods relatin

Details Transglutaminase cross-linkable polypeptides and methods relatin Transglutaminase cross-linkable polypeptides and methods relatin

1993-08-13

1995-06-27

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 530324, 530326, 530327, 530328, 530329, 530345, 530350, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

054280141

ABSTRACT:
Polypeptides of from 3-120 amino acid residues comprising a segment of the formula Gln-Y-Lys, wherein Y is a spacer peptide of 1 to 12, wherein said polypeptides are cross-linkable by a transglutaminase, homo- and copolymers containing such polypeptides are disclosed. The homo- and co-polymers disclosed herein are useful in tissue sealant and wound healing formulations.

REFERENCES:
patent: 4455290 (1984-06-01), Olexa et al.
The Merck Index, 11th edition, pp. 4018-4019.

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