Transglutaminase and gene encoding same

Details Transglutaminase and gene encoding same Transglutaminase and gene encoding same

1999-02-25

2000-02-01

Degen, Nancy

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435183, 530350, C12N 910

Patent

active

060201789

ABSTRACT:
A pair of degenerate oligonucleotide primers can amplify transglutaminase-specific fragments of known transglutaminase genes. The primers are also used to obtain new transglutaminase gene products. The nucleotide sequence of a novel transglutaminase gene (termed TG.sub.X) is presented.

REFERENCES:
patent: 5607849 (1997-03-01), Yasueda et al.
Aeschlimann, et al., "Isolation of a cDNA Encoding a Novel Member of the Transglutaminase Gene Family from Human Keratinocytes,"The Journal of Biological Chemistry 273:3452-3460 (1998).
Kim et al., "The Deduced Sequence of the Novel Protransglutaminase E (TGase3) of Human and Mouse," The Journal of Biological Chemistry 268:12682-12690 (1993).
Weraachakul-Boonmark, "Cloning and expression of chicken erythrocyte transglutaminase," Biochemistry 89:9804-9808 (1992).

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