Transgenically produced antithrombin III

Details Transgenically produced antithrombin III Transgenically produced antithrombin III

1995-02-21

1998-12-01

Low, Christopher S.F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530393, 530392, 530386, 530380, 530360, 530412, 530832, 514 8, 514 21, 4353201, 4351723, 4351721, 435325, 800 2, 4241521, 424535, 930240, C12P 2106, C12N 948

Patent

active

058437053

ABSTRACT:
This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition which comprises N-acetylgalactosamine (GaINAc) along with fucose, N-acetylglucosamine, galactose, mannose, and N-acetylneuraminic acid/N-glycolyneuraminic acid. The monosaccharide composition differs with that of plasma derived ATIII (phATIII). It has been found that tgATIII has an increased clearance rate when compared to phATIII.

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Bock, S. et al., "Cloning and Expression of the cDNA for Human Antithrombin III", Nucleic Acids Research, vol. 10 (24), pp. 8113-8125 (1982).
Wall, R., "Transgenic Livestock: Progress and Prospects for the Future", Theriogenology, vol. 45, pp. 57-68 (1996).
Fan et al J. of Biol. Chem. 268(23):17588-96 1993.
Cole et al. J. of Cellular Biochemistry Supplement O (180). 1994 p. 265.
Edmundo et al J. of Cellular Biochemistry Supplement O(180) 1994 p. 265.
Wall Theriogenology 45:57-68 (1996).

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