Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2003-12-23
2009-11-10
Falk, Anne-Marie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C536S023400, C536S024100, C435S325000
Reexamination Certificate
active
07615676
ABSTRACT:
A transgenic screen and method for screening biological and chemical test substances or molecules for their ability to influence or modulate the production of BDNF in cells, includes a fusion gene having a zebrafish BDNF gene fragment (promoter) and a fluorescent marker gene inserted downstream of the BDNF gene fragment. When the fusion gene is injected into a zebrafish embryo, the BDNF promoter causes the production of fluorescent protein in various cell types. The embryo is exposed to a test substance for determining the effect thereof on the production of the fluorescent marker protein.
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Nilsson
Heinrich Gerhard
Huynh Gigi
Agarwal, P.C. Dinesh
Falk Anne-Marie
Sgagias Magdalene K.
U.S. Department of Veterans Affairs
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