Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2011-04-19
2011-04-19
Crouch, Deborah (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S008000
Reexamination Certificate
active
07928283
ABSTRACT:
An object of the present invention is to develop a new alternative splicing reporter system and to provide a method for detecting alternative splicing patterns in a multicellular organism more precisely, a method for identifying efficiently substances and gene regions that affect alternative splicing in a multicellular organism, and the like by utilizing the alternative splicing reporter system. Specifically, the present invention relates to a method for detecting alternative splicing in a multicellular organism, and a method for identifying substances and gene regions that affect alternative splicing in a multicellular organism, which use a DNA construct in which at least two different reporter genes are inserted into a specific gene that undergoes alternative splicing, or a combination of DNA constructs (a combination of at least two different DNA constructs) in which DNA construct a reporter gene is inserted into a specific gene that undergoes alternative splicing.
REFERENCES:
Cameron, E.R. Recent Advances in Transgenic Techology, Molec. Biotech. 1997, vol. 7, pp. 253-265.
Sigmund, C.D. Viewpoint: Are Studies in Genetically Altered Mice Out of Control. Arteroscler. Throm. Vasc. Biol. 2000, vol. 20, pp. 1425-1429.
Niemann, H. Transgenic Farm Animals Get Off the Ground. Transg. Res. 1998, vol. 7, pp. 73-75.
Smith. Gene Transfer in Higher Animals: Theoretical Considerations and Key Concepts. J. Biotech. 2002, vol. 99, pp. 1-22.
Montoliu. Gene Transfer Strategies in Animal Transgenesis. Cloning and Stem Cells. 2002, vol. 4, pp. 39-46.
Ristevski. Making Better Transgenic Models. Molecular Biotechnology, vol. 29, pp. 153-163.
Prelle et al. Establishment of Pluripotent Cell Lines from Vertebrate Sprecies-Present Status and Future Prospects. Cells Tissues Organs, 1989, vol. 165, pp. 220-236.
Hagiwara Masatoshi
Kuroyanagi Hidehito
Carmody & Torrance LLP
Crouch Deborah
Kinopharma, Inc.
LandOfFree
Transgenic reporter system that reveals expression profiles... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transgenic reporter system that reveals expression profiles..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic reporter system that reveals expression profiles... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2678129