Transgenic rats containing at least one human gene which partici

Details Transgenic rats containing at least one human gene which partici Transgenic rats containing at least one human gene which partici

1995-01-17

1998-03-24

Ziska, Suzanne E.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 424 9466, C12N 1500, A61K 3846

Patent

active

057314896

ABSTRACT:
The present invention relates to transgenic rats in the genome of which at least one human gene is integrated the gene product of which participates in blood pressure control. More specifically, the invention relates to transgenic rats and their offspring exhibiting increased blood pressure (>90/>140 mm Hg) or high blood pressure (>95/>160 mm Hg). Finally, the invention relates to processes for the production of the transgenic rats of the present invention and their offspring and their use for pharmacological tests.

REFERENCES:
Kageyama et al. Biochemistry 23:3603, 1984.
Zeh et al. FASEB 6(4): Abstract A1344, 1992.
Ganten et al. Hypertension 17(6 nts):843, 1991.
Ganten et al PNAS 89:7806, 1992.
Miyazaki et al. PNAS 89:5999, 1984.
Mullins et al Nature 344:541, 1990.
Mullins et al, Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene, Nature 344, pp. 541-544, 1990.

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