Multicellular living organisms and unmodified parts thereof and – Method of introducing a polynucleotide molecule into or... – The polynucleotide alters fat – fatty oil – ester-type wax – or...
Patent
1995-01-12
1998-03-03
McElwain, Elizabeth
Multicellular living organisms and unmodified parts thereof and
Method of introducing a polynucleotide molecule into or...
The polynucleotide alters fat, fatty oil, ester-type wax, or...
435 691, 4351721, 4351723, 4353201, 536 231, 536 2372, A01H 500, C12N 1533, C12N 1584
Patent
active
057237506
ABSTRACT:
The present invention provides a method for protecting plants against infection by pathogenic plant viruses comprising administering to the plant a nucleic acid, encoding a pathogenic plant virus protein, containing substitutions in the genetic sequence which result in the replacement of amino acids having carboxylate side chains with uncharged amino acids and which have the phenotypic effect of displacing wild type coat proteins in a wild type virus and inhibiting the ability of the wild type virus to disassemble under conditions whereby the nucleic acid is expressed as a mutant coat protein within the plant. Also provided is a nucleic acid, encoding a pathogenic plant virus protein, containing substitutions in the genetic sequence which result in the replacement of amino acids having carboxylate side chains with uncharged amino acids and which have the phenotypic effect of displacing wild type coat proteins in a wild type virus and inhibiting the ability of the wild type virus to disassemble.
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Culver et al., "Site-Directed Mutagenesis Confirms the Involvement . . . ," Virology 206:724-730, 1995 (no month or day given).
Stubbs et al., Abstract, "Tobacco mosaic virus: structure, assembly, and disassembly," FASEB Conference on Viral Assembly, Saxtons River, Vermont, held Jul. 26-31, 1992.
I. Potrykus, "Gene Transfer to Plants: Assessment . . . ," Ann. Rev. Plant Physiol. Plant Mol. Biol. 42:205-225, 1991 (no month or day given).
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Wilson, T.M.A. (1993) Proc. Natl Acad Sci USA 90:3134-3141.
Nejidat et al (1990) Physiologia Plantarum 80:662-668.
Register et al (1988) Virology 166:524-532.
Culver James N.
Stubbs Gerald
McElwain Elizabeth
Univ. of Maryland Biotechnology Institute
Vanderbilt University
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