Chemistry: molecular biology and microbiology – Plant cell or cell line – per se ; composition thereof;... – Plant cell or cell line – per se – contains exogenous or...
Reexamination Certificate
2006-02-07
2006-02-07
Collins, Cynthia (Department: 1638)
Chemistry: molecular biology and microbiology
Plant cell or cell line, per se ; composition thereof;...
Plant cell or cell line, per se, contains exogenous or...
C530S387100, C536S023530, C800S296000, C800S298000
Reexamination Certificate
active
06995014
ABSTRACT:
The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.
REFERENCES:
patent: 4762785 (1988-08-01), Comai
patent: 4771002 (1988-09-01), Gelvin
patent: 4816397 (1989-03-01), Bois et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4956282 (1990-09-01), Goodman et al.
patent: 5202422 (1993-04-01), Hiatt et al.
patent: 5639947 (1997-06-01), Hiatt et al.
patent: 5959177 (1999-09-01), Hein et al.
patent: WO87/00865 (1987-02-01), None
patent: WO88/04936 (1988-07-01), None
Azipura, et al., “Oral Vaccination: Identification of Classes of Proteins that Provoke an Immune Response upon Oral Feeding”,J. Exp. Med.,167:440-451 (1988).
Carayannopoulos, et al., “Recombinant Human IgA Expressed in Insect Cells”,Proc. Natl. Acad. Sci., USA, 91:8348-8352 (1994).
Chrisppels, Maarten J., “Sorting of Proteins in the Secretory System”,Annu. Bev. Plant Physiol. Plant Mol. Biol., 42:21-53 (1991).
Cocking, et al., “Gene Transfer in Cereals”,Science, 236:1259-1262 (1987).
During, 1988 (Jul. 9), Wundinduzier bare Expression und Sekretion von T4 Lysozym and monoklonalen Antikorpern in Nicotiana Tabacum. Dissertation, Univeristy of Koln, FRG. pp. 13-16, 65-78, 87-89, 103-105, 108-110, 112-118, 120-126, and 135-158. Also, English translation.
During, et al., “Synthesis and Self-Assembly of a Functional Monoclonal Antibody in Transgenic Nicotiana Tabacum”,Plant Molecular Biology, 15:281-293 (1990).
During and Hippe, “Synthesis, Assembly and Targeting of Foreign Chimeric Proteins in Transgenic Nicotiana Tabacum Cells”,Biol. Chem. Hoppe Seyler, Gesellschaft fur Biologische Chemie, 370:888 (1989).
Edelman, et al., “The Covalent Structure of an Entire γG1 Immunoglobulin Molecule”,Proc. Natl. Acad. Sci., USA, 63:78-85 (1969).
Eicholtz, et al., “Expression of Mouse Dihydrofolate Reductase Gene Confers Methotrexate Resistance in Transgenic Petunia Plants”,Somatic Cell and Molecular Genetics, 13(1):67-76 (1987).
Graves and Goldman, “The Transofrmation of Zea Mays Seedlings with Agrobacterium Tumefaciens Detection of T-DNA Specific Enzyme Activities”,Plant Molecular Biology, 7:43-50 (1986).
Hein, et al., “Evaluation of Immunoglobulins from Plant Cells”,Biotechnol. Prog.,7:455-461 (1991).
Hiatt, et al., “Production of Antibodies in Transgenic Plants”,Nature, 342:76-78 (1989).
Horsch, et al., “A Simple and General Method for Transferring Genes into Plants”,Science, 227:1229-1231 (1985).
Hunt, et al., “Plant Cells Do Not Properly Recognize Animal Gene Polyadenylation Signals”,Plant Molecular Biology, 8:23-35 (1987).
Lefebvre, et al., “Mammalian Metallothionein Functions in Plants”,Biotechnology, 5:1053-1056 (1987).
Lutcke, et al., “Selection of AUG Initiation Codons Differs in Plants and Animals”,Embo Journal, 6(1):43-48 (1987).
Ma, et al., “Assembly of Monoclonal Antibodies with IgGI and IgA Heavy Chain Domains in Transgenic Tobacco Plants”,Eur. J. Immunol.,24;131-138 (1994).
Mach, Jean-Pierre, “In Vitro Combination of Human Bovine Free Secretory Component with IgA of Various Species”,Nature, 228:1278-1282 (1970).
Pautot, et al., “Expression of a Mouse Metallothionein Gene in Transgenic Plant Tissues”,Gene, 77:133-140 (1989).
Poehlman, John M., Breeding Field Crops; AVI Publishing Co. Inc., Chapter 3: Gene Recombination in Plant Breeding pp. 38-63 (1986).
Thiele, et al, “Mammalian Metallothionein is Function in Yeast”,Science, 231:854-856 (1986).
Thorens and Vassalli, “Chloroquine and Ammonium Chloride Prevent Terminal Glycosylation of Immunoglobulins in Plasma Cells without Affecting Secretion”,Nature, 321:618-620 (1986).
Vandekerckhove, et al, “Enkephalins Produced in Transgenic Plants Using Modified 2S Seed Storage Proteins”,Biotechnology, 7:929-932 (1989).
von Heijne, Gunnar, “Signal Sequences: The Limits of Variation”,J. Mol. Biol.,184:99-105 (1985).
Hein Mich B.
Hiatt Andrew
Ma Julian K-C
Collins Cynthia
Foley & Lardner LLP
The Scripps Research Institute
LandOfFree
Transgenic plants expressing assembled secretory antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transgenic plants expressing assembled secretory antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic plants expressing assembled secretory antibodies will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3644965