Transgenic plants expressing assembled secretory antibodies

Details Transgenic plants expressing assembled secretory antibodies Transgenic plants expressing assembled secretory antibodies

1996-05-03

1999-09-28

Robinson, Douglas W.

Multicellular living organisms and unmodified parts thereof and

Method of introducing a polynucleotide molecule into or...

Nonplant protein is expressed from the polynucleotide

800295, 435419, 435 691, 4353201, 536 235, 536 2353, 536 241, C12N 1500, C12N 1529, C12N 1582, A01H 500

Patent

active

059591773

ABSTRACT:
The present invention relates to expression and assembly of foreign multimeric proteins--e.g., antibodies--in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.

REFERENCES:
patent: 4762785 (1988-08-01), Comai
patent: 4771002 (1988-09-01), Gelvin
patent: 4816397 (1989-03-01), Bois et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4956282 (1990-09-01), Goodman et al.
patent: 5639947 (1997-06-01), Hiatt et al.
Carayannopoulos, et al., "Recombinant human IgA expressed in insect cells", Proc. Natl. Acad. Sci., USA, 91:8348-8352 (1994).
Ma, et al., "Assembly of monoclonal antibodies with IgGL and IgA heavy chain domains in transgenic tobacco plants", Eur. J. Immunol., 24:131-138 (1994).
Mach, Jean-Pierre, "In vitro combination of human and bovine free secretory component with IgA of various species", Nature, 228:1278-1282 (1970).
Heijne, J. Mol. Biol. 184: 99-105 (1985).
Chrispeels, Ann. Rev. Plant. Physiol. Plant Mol. Biol. 42: 21-53 (1991).
Hein, et al., Biotechnol. Prog. 7: 455-461 (1991).
Hiatt, et al., Nature 342: 76-78 (1989).
Pautot, et al., Gene 77: 133-40 (1989).
Eichholtz, et al., Somatic Cell and Molec. Genet. 13: 67-76 (1987).
LeFebvre, et al., Bio/Technology 5: 1053-6 (1987).
Thiele, et al., Science 231: 854-6 (1986).
Vandekerckhove, et al., Bio/Technology 7: 929-932 (1989).
Lutcke, et al., EMBO J. 6: 43-8 (1987).
Hunt, et al., Plant Molec. Biol. 8: 23-25 (1987).
Azipurua, et al., J. Exp. Med. 167: 440-451 (1988).
During, et al., Plant Molec. Biol. 15: 281-293 (1990).
Thorens, et al., Nature 321: 618-630 (1986).
Edelman, et al., PNAS USA 63: 78-85 (1969).
Horsch, et al., Science 227: 1229-1231 (1985).
Cocking, et al., Science 236: 1259-62 (1987).
During and Hippe, Biol. Chem. Hoppe Seyler, Gesellschaft fur Biologische Chemie 370: 888 (1989).

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