Multicellular living organisms and unmodified parts thereof and – Method of introducing a polynucleotide molecule into or... – The polynucleotide alters fat – fatty oil – ester-type wax – or...
Patent
1995-01-18
1996-12-31
Robinson, Douglas W.
Multicellular living organisms and unmodified parts thereof and
Method of introducing a polynucleotide molecule into or...
The polynucleotide alters fat, fatty oil, ester-type wax, or...
435 691, 4351723, 4352404, A01H 500, C12N 1582
Patent
active
055896251
ABSTRACT:
This invention discloses transgenic plants, such as transgenic tobacco and potato, having resistance to multiple viral taxonomic groups using parts of the 2,5A oligoadenylate pathway. In particular, said plants are genetically engineered to contain a DNA sequence encoding at least one polypeptide having a 2,5A synthetase activity. By this means a step in the 2,5A oligoadenylate pathway heretofore believed to be missing in all plants is provided so that viral infection in the transgenic plants is inhibited via a 2,5A dependent endonuclease. Moreover, this invention relates to a process for the production of said transgenic plants by transfection with a genetically engineered DNA sequence encoding at least one polypeptide having a 2,5A synthetase activity.
REFERENCES:
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Truve, et al., Principles and background for the construction of transgenic plants displaying multiple virus resistance, Arch Virol (1994) [Suppl] 9:41-50.
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Schroder, et al., Protection of HeLa-T4.sup.+ cells against human immunodeficiancy virus (HIV) infection after stable transfection with HIV LTR-2.degree.,5'-Oligoadenylate synthetase hybrid gene.sup.1, Research Communications, vol. 4, pp. 3124-3130, Oct. 1990.
Sela, et al., Resistance systems related to the N gene and their comparison with interferon, 1987 Plant Resistance to Viruses., Wiley, Chichester (Ciba Foundation Symposium 133) P 109-119.
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Kelve Merikke
Saarma Mart
Teeri Teemu
Truve Erkki
Kemira Oy, Biotech
McElwain Elizabeth F.
Robinson Douglas W.
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