Transgenic pig with altered incretin function

Details Transgenic pig with altered incretin function Transgenic pig with altered incretin function

2011-04-05

2011-04-05

Bertoglio, Valarie (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S014000, C800S009000

Reexamination Certificate

active

07919673

ABSTRACT:
The present invention relates to transgenic pigs containing a dominant-negative incretin hormone receptor, namely the dominant-negative human glucose-dependent insulinotropic polypeptide receptor. The present invention furthermore relates to uses of these transgenic pigs as clinically relevant animal model systems for studying the pathogenesis and novel therapies for diabetes mellitus type 2, particularly for the maintenance and expansion of pancreatic β-cell mass.

REFERENCES:
patent: 0 979 872 (2000-02-01), None
Herbach et al, 2005, Regulatory Peptides, 125:103-117.
Hofmann et al. EMBO reports, 2003, 4:1054-1060.
Gerrity, Diabetes, 2001, 50:1654-1665.
Renner, S. et al., “Glucose intolerance and reduction of pancreatic b-cell mass in transgenic pigs expressing a dominant-negative GIP receptor(GIPRdn) in the pancreatic islets,”Swine in Biomedical Research Conference Proceedings, Apr. 2, 2008, p. 55, XP-002518911.
Renner, S. et al., “Impaired incretin effect in transgenic pigs expressing a dominant negative receptor for glucose-dependent insulinotropic polypeptide (GIP),”National Genome Research Network. Nov. 2007, Abstract.

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