Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1996-10-16
1998-12-15
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 424 91, 4351723, 935 60, C12N 500, C12N 1500, A61K 4900
Patent
active
058499997
ABSTRACT:
Disclosed is a transgenic non-human mammal that expresses in its brain a transgene encoding an APP-C100 polypeptide with the flag amino acid sequence fused to the amino terminus of the APP-C100. This transgenic non-human mammal is an improved in vivo model for Alzheimer's disease-like neuropathology and associated cognitive impairment. The improvement includes accelerated development of AD-like neuropathology and cognitive impairment. The AD-like neurodegeneration and associated cognitive impairment in mice produced according to this invention appear at least six months sooner than they appear in APP-C100-expressing transgenic mice.
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Berger-Sweeney Joanne
Neve Rachael L.
Crouch Deborah
The McLean Hospital Corporation
Wellesley College
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