Transgenic non-human mammals producing BSSL variants

Details Transgenic non-human mammals producing BSSL variants Transgenic non-human mammals producing BSSL variants

1995-05-19

1998-06-09

Rories, Charles C. P.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 800DIG2, 800DIG4, 4351723, 435 691, C12N 1500, C07K 100

Patent

active

057637393

ABSTRACT:
The present invention relates to novel polypeptides which are variants of Bile Salt-Stimulated Lipase (BSSL; EC 3.1.1.1). It also relates to DNA molecules encoding the said polypeptides, and to subproducts comprising the said DNA molecules. The invention further relates to processes for producing the said BSSL variants and for producing transgenic non-human mammals capable of expressing the BSSL variants.
Furthermore the invention relates to such transgenic animals as well as to infant formulas comprising milk from such transgenic animals. The invention also relates to pharmaceutical compositions comprising the said polypeptides; and the use of the said polypeptides and DNA molecules for the manufacture of medicaments.

REFERENCES:
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R. Rieger et al., Glossary of Genetis & Cyzogenetics, 4.sup.th Ed., Springer-Verlag, Berlin NY, 1976, p. 282.
J. Han et al. Biochem. 26: 1617-1625 ('87).
C. Pittus et al. PNAS 85: 5874-5878 ('88).

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