Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2007-09-04
2007-09-04
Chen, Shin-Lin (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S013000, C800S014000, C536S023500, C536S024100
Reexamination Certificate
active
10378393
ABSTRACT:
A transgenic non-human mammal whose germ cells and somatic cells contain a constructively activated tyrosine kinase receptor introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammals can be used as ligand-independent in vivo models for the identification and development of selective tyrosine kinase modulators for the treatment of cancer.
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Bol David K.
Carboni Joan M.
Lee Francis Y.
Rowley Ronald B.
Wong Tai W.
Bristol--Myers Squibb Company
Chen Shin-Lin
Golian Paul D.
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