Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2006-02-01
2008-11-25
Ton, Thaian N. (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C435S325000
Reexamination Certificate
active
07456333
ABSTRACT:
Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopoietic or embryonic stem calls. The transgenic non-human mammals can be produced using as a strategy the expression of genes involved in said pathologies by means of a promoter that directs the expression of a transgene in Sca-1+cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of compounds for the treatment and/or prevention of the diseases. Also disclosed are DNA construct and methods useful for producing the non-human transgenic mammals.
REFERENCES:
patent: 5491283 (1996-02-01), Groffen et al.
patent: WO 01/02860 (2001-01-01), None
patent: WO 02/059361 (2002-08-01), None
Cameron et al, Molecular Biotechnology, 1997, 7: 253-265.
Houdebine et al, Transgenic Research , 2000, 9: 305-320.
Kolb et al, Gene, 1999, 227:21-31.
Miles C, Sanchez MJ, Sinclair A, Dzierzak E. Development. 1997; 124(2):537-47.
Honda H, Oda H, Suzuki T, Takahashi T, Witte ON, Ozawa K, Ishikawa T, Yazaki Y, Hirai H. Blood. 1998; 91(6):2067-75.
Sanchez Garcia I, Current Genomics 2000; vol. 1,: 71-80.
Dyke et al, Cell, 108: 135-144, 2002.
Bernardi et al Oncogene, 21: 3445-3458, 2002.
Cobaleda et al Blood. Feb. 1, 2000;95(3):1007-13.
Bonnet et al Nat Med. Jul. 1997;3(7):730-7.
Gordon et al, J Clin Pathol. 1999; 52(10):719-22.
Sefton et al; “Conserved and Divergent Roles for Members of the Snail Family of Transcription Factors in the Chick and Mouse Embryo”, 1998, Development, vol. 125, pp. 3111-3121.
Ewan R. Cameron, “Recent Advances in Transgenic Technology”, Molecular Biotechnology, 1997, pp. 253-265, vol. 7, Humana Press, Inc.
Louis Marie Houdebine, “Transgenic Animal Bioreactors”, Transgenic Research, 2000, pp. 305-320, No. 9, Kluwer Academic Publishers, The Netherlands.
Andreas F. Kolb et al., “Insertion of a Foreign Gene into the β-casein Locus by Cre-mediated Site-Specific Recombination”, Gene, 1999, pp. 21-31, No. 227, Elsevier Science B.V.
Colin Miles et al., “Expression of the Ly-6E.1 (Sca-1) Transgene in Adult Hematopoietic Stem Cells and the Developing Mouse Embryo”, Development, 1997, pp. 537-547, No. 124, The Company of Biologist Limited, Great Britain.
Hiroaki Honda et al., “Development of Acute Lymphoblastic Leukemia and Myeloproliferative Disorder in Transgenic Mice Expressing p210bcr/abl: A Novel Transgenic Model for Human Ph1-Positive Leukemias”, Blood, Mar. 15, 1998, pp. 2067-2075, vol. 91, No. 6.
I. Sánchez-Garcia et al., “Chromosomal Abnormalities, Cancer and Mouse Models: The Critical Role of Translocation-Associated Genes in Human Cancer”, Current Genomics, 2000, pp. 71-80, vol. 1, No. 1, Bentham Science Publishers, Ltd.
International Search Report dated Mar. 7, 2003 (Four (4) pages).
International Preliminary Examination Report dated Apr. 6, 2004 (Four (4) pages).
Garcia Isidro Sanchez
Losada Jesus Perez
Consejo Superior de Investigaciones
Crowell & Moring LLP
Singh Anoop
Ton Thai-an N.
Universidad de Salamanca
LandOfFree
Transgenic non-human mammals as models for human pathologies... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transgenic non-human mammals as models for human pathologies..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic non-human mammals as models for human pathologies... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4029359