Transgenic non-human animals having targeting endogenous lymphoc

Details Transgenic non-human animals having targeting endogenous lymphoc Transgenic non-human animals having targeting endogenous lymphoc

1996-07-08

1999-01-12

Ziska, Suzanne E.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 435 71, 800DIG1, 536 231, C12N 1500, C07H 2104, C01N 3353

Patent

active

058593128

ABSTRACT:
The invention provides transgenic non-human animals and transgenic non-human mammalian cells having at least one functionally disrupted lymphocyte transduction locus, particularly a CD4 locus, targeting constructs used to produce such transgenic stem cells and animals, methods and targeting constructs for inactivating or suppressing expression of endogenous lymphocyte transduction gene loci, transgenes encoding heterologous lymphocyte transduction proteins, and nonhuman animals that express a human lymphocyte transduction protein and lack expression of a cognate murine lymphocyte transduction protein.

REFERENCES:
patent: 5530178 (1996-06-01), Mak
Makre et al. I. Immune 146 (8): 2522, 1991.
Diamond et al. PNAS 85:1615, 1988.
Travis Science 256:1392, 1992.
Rohemsella et al. Nature 353:100, 1991.
Killeen et al. FMBO J 11(12): 4329, 1992.
Killeen et al. J. Cell. Biochem, Syrol 14A, 1990 Abstract D 210.
Gross et al. J. Cell Biochem, Syprol 14 B, 1990 Abstract CE 115.

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