Transgenic non-human animals for pharmacological and...

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

Reexamination Certificate

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C800S008000, C800S003000

Reexamination Certificate

active

07544854

ABSTRACT:
The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.

REFERENCES:
patent: 4994384 (1991-02-01), Prather et al.
patent: 5057420 (1991-10-01), Massey
patent: 5654182 (1997-08-01), Wahl et al.
patent: 5677177 (1997-10-01), Wahl et al.
patent: 5721367 (1998-02-01), Kay et al.
patent: 6011197 (2000-01-01), Strelchenko et al.
patent: 6020143 (2000-02-01), St. George-Hyslop et al.
patent: 0 453 319 (1991-10-01), None
patent: 1 206 906 (2002-05-01), None
patent: WO 93/03164 (1993-02-01), None
patent: WO 00/31237 (2000-06-01), None
patent: WO 01/11951 (2001-02-01), None
van Vlijmen, BJM, et al. J Biol Chem 271(48):30595-30602, 1996.
Fuggar, L Curr Opin Immunol 12:698-703, 2000.
Tomei, L et al. Hum Genet 84:89-91, 1989.
Denning, C and H Priddle Reproduction 126:1-11, 2003.
Gonzalez et al., (1999) “Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis,”Cancer Lett.143:199-204.
Gonzalez, F.J., et al. (2001) “Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice,”Mutation Res.477:79-87.
Kemper, B. (1998) “Regulation of cytochrome P450 gene transcription by phenobarbital,”Prog Nucleic Acid Res. Mol. Biol.61:25-64.
Laub, R., et al. (2000) “A multiple transgenic mouse model with a partially humanized activation pathway for helper T cell responses,”J. Immunol. Methods246:37-50.
McKinnon, R.A., et al. (1998) “Cytochrome P450 knockout mice: new toxicological models,”Clin. Exp. Pharmacol. Physiol.25:783-787.
Mickisch, G.H., et al. (1991) “Multidrug resistant transgenic mice as a novel pharmacologic tool,”BioEssays13:381-387.
Simula, A.P., et al. (1993) “Heterologous expression of drug-metabolizing enzymes in cellular and whole animal models,” Toxicology 82:3-20.
Van Dijk et al., (1991) “Effect of transgenic expression of human α1-acid glycoprotein (AGP) on the glycosylation of human and mouse AGP in various transgenic mouse sera,”Eur. J. Cell Biol.55:153-148.
Wolf, C.R., et al., (1998) “Use of transgenic animals in understanding molecular mechanisms of toxicity,”J. Pharm. Pharmacol.50:567-574.
Bradley, M. O. et al. (1984) “Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines”Nature309:255-258.
Robertson, et al. (1986) “Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector”Nature322:445-448.
Schinke et al. (1999) “Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen”PNAS USA96:3975-80.
Supplementary European Search Report from corresponding European Patent Application No. EP 02 71 7850.
Suraokar et al. (2000) “Targeting sheep”Nature405:1004-1005.

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