Transgenic non-human animals depleted in a mature lymphocytic ce

Details Transgenic non-human animals depleted in a mature lymphocytic ce Transgenic non-human animals depleted in a mature lymphocytic ce

1996-12-05

2000-02-08

Chambers, Jasmine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 800DIG2, 800DIG3, 4351723, 4353201, 4353171, 935111, C12N 1500

Patent

active

06023010&

ABSTRACT:
Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprised is a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.

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