Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1995-10-10
1998-06-23
Ziska, Suzanne E.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
5303871, 5303881, 53038815, 5303882, 800 2, 800DIG1, 4241841, 43524027, 43524026, 435 691, 536 231, 536 2353, A61K 3900, C12N 500, C12N 1500, C12P 2106, C07K 1600
Patent
active
057704295
ABSTRACT:
The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
REFERENCES:
patent: 4204244 (1980-05-01), Fell et al.
patent: 4474893 (1984-10-01), Reodig
patent: 4634666 (1987-01-01), Engleman et al.
patent: 4714681 (1987-12-01), Reodj
patent: 5001065 (1991-03-01), Larrick
patent: 5104674 (1992-04-01), Chen et al.
patent: 5175384 (1992-12-01), Krimpenfort
patent: 5434340 (1995-07-01), Krimpenfort
patent: 5530101 (1996-06-01), Queen et al.
patent: 5565354 (1996-10-01), Ostberg
patent: 5569825 (1996-10-01), Lonberg et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5591669 (1997-01-01), Krimpenfort et al.
patent: 5653977 (1997-08-01), Satel
Ostberg, L. et al., "Human X (Mouse .times. Human) Hybridomas Stably Producing Human Antibodies", Hybridoma, vol. 2, No. 4, pp. 361-367 (1983).
Shifts in Basic & Clinical Immunology, Chapter 2, Nuscove et al Nature 314: 330, 1985.
Abbas, A.K. et al., Cellualr and Molecular Immunology, W.B. Saunders Company, Philadelphia, PA, pp. 90-92 (1991).
Adra, C.N. et al., "Cloning and expression of the mouse pgk-a gene and the nucleotide sequence of its promoter" Gene 60:65-74 (1987).
Baer, R. et al., "Immunoglobulin V.sub.h Genes are Transcribed by T Cells in Association with a New 5' Exon" J. Exp. Med. 167:2011-2015 (Jun. 1988).
Barbas, S. M. et al., "Human Autoantibody Recognition of DNA" Proc. Natl. Acad. Sci. USA 92:2529-2533 (Mar. 1995)
Boer, P.H. et al., "Polymorphisms in the Coding and Noncoding Regions of Murine Pgk-1 Alleles" Biochem. Genet. 28 (5/6) :299-308 (1990).
Bollag, R.J. et al., "Homologous Recombination in Mammalian Cells" Annu. Rev. Genet. 23:199-225 (1989).
Bosma, G.C. et al., "A severe combined immunodeficiency mutation in the mouse" Nature 301:527-530 (Feb. 10, 1983).
Burke, D.T. et al., "Cloning of Large Segments of Exogenous DNA into Yeast by means of Artificial Chromosome Vectors" Science 236:806-812 (May 1987).
Bye, J.M. et al., "Germline Variable Region Gene Segment Derivation of Human Monoclonal Anti-Rh (D) Antibodies, Evidence for Affinity Maturation by Somatic Hypermutation and Repertoire Shift" J. Clin. Invest. 90:2481-2490 (Dec. 1992).
Casali, P. et al., "Frequency of B Cells Committed to the Production of Anribodies to Insulin in Newly Diagnosed Patients With Insulin-Dependent Diabetes Mellitus and Generation of High Affinity Human Monoclonal IgG to Insulin" J. Immunol. 144(10)3741-3747 (May 5, 1990).
Casali, P. et al., "High-Affinity Antibodies to ssDNA are produced by CD5 B Cells in Systemic Lupus Erythematosus Patients" J. Immunol. 143 (11):3476-3483 (Dec. 1, 1989).
Cha, S. et al., "Combinatorial Autoantibodies to Dihydrolipoamide Acetyltransferase, the Major Autoantigen of Primary Biliary Cirrhosis" Proc. Natl. Acad. Sci. USA 90:2527-2531 (Mar. 1993).
Cha, S. et al., "Heterogeneity of Combinatorial Human Auotantibodies Against PDC-E2 and Biliary Epithelial Cells in Patients with Primary Biliary Cirrhosis" Hepatol. 20(3) :574-583 (1994).
Chen, J. et al., "Mutation of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the J.sub.h locus" EMBO J. 12(12) :4635-4645 (1993).
Clackson, T. et al., "Making antibody fragments using phage display libraries" Nature 352: 624-628 (Aug. 15, 1991).
Ditzel, H.J. et al., "The nature of the autoimmune antibody reportoire in human immunodeficiency virus type 1 infection" Proc. Natl. Acad. Sci. USA 91:3710-3714 (Apr. 1994).
Doetschman, T. et al., "Targetted correction of a mutant HPRT gene in mouse embryonic stem cells" Nature 330:576-578 (Dec. 10, 1987).
Ehrenstein, M.R. et al., "Production of Human Monoclonal Antibodies to Myeloperoxidase" JH. Immunol. 76:617-620 (1992).
Gorick, B. D. et al., "Three Epitopes on the Human Rh Antigen D Recognized by I-Labeled Human Monoclonal IgG Antibodies" Vox Sang 55:165-170 (1988).
Hansen, M.B., "Interleukin-6 Autoantibodies: Possible Biological and Clinical Significance" Leukemia 9:1113-1115 (1995).
Hasty, P. et al., "Introduction of a subtle mutation into the Hox-2.6 locus in embyronic stem cells" Nature 350:243-246 (Mar. 21, 1991).
Huse, W.D. et al., "Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda" Science 246:1275-1281 (Dec. 8, 1989).
Ichiyoshi, Y. et al., "A Human Anti-Insulin IgG Autoantibody Apparently Arises Through Clonal Selection from an Insulin-Specific `Germ-Line` Natural Antibody Template" J. Immunol. 154:226-238 (1995).
Isaacs, J.D. et al., "Humanised Monoclonal Antibody Therapy for Rheumatoid Arthritis" The Lancet 340:748-752 (Sep. 26, 1992).
Jakobovits, A. et al., "Analysis of homozygous mutant chimeric mice: Deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production" Proc. Natl. Sci. USA 90:2551-2555 (Mar. 1993).
Kasaian, M.T. et al., "Identification and Analysis of a Novel Human Surface CD5 B Lymphocyte Suset Producing Natural Antiobodies" J. Immunol. 148:2690-2695 and 2698-2702 (May 1, 1992).
Kohler, G. and Millstein, C., "Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion" Eur. J. Immunol. 6:511-519 (1976).
Lanzavecchia, A., "Antigen-specific interaction between T and B cells" Nature 314:537-539 (Apr. 11, 1985).
Laird, P.W. et al., "Simplified mammalian DNA isolation procedure" Nucl. Acids Res. 19(5):4293 (1991).
McCormick, M.K. et al., "Construction of human chromosome 21-specific yeast artificial chromosomes" Proc. Natl. Acad. Sci. USA 86:9991-9995 (Dec. 1989).
McMahon, A.P. and Bradley, A., "The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain" Cell 62:1073-1085 (1990).
Manz, J. et al., "Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains" J. Exp. Med. 1363-1381 (Oct. 1988).
Marcu, K.B. et al., "The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation" Gene 32:481-485 (19840.
Mombaerts, P. et al., "Cration of a large genomic deletion at the T-cell antigen receptor .beta.subunit locus in mouse embryonic stem cells by gene targeting" Proc. Natl. Acad. Sci. USA 3084-3087 (Apr. 1991).
Mombaerts, P. et al., "RAG-1-deficient mice have no mature B and T lymphocytes" Cell 68:869-877 (1992).
Nakamura, M. et al., "Probing The Normal and Autoimmune B Cell Repertoire With Epstein-Barr Virus, Frequency of B Cells Producing Monoreactive High Affinity Autoantibodie in Patients With Hashimoto's Disease and Systemic Lupus Erythematosus" J. Immunol. 141(12):4165-4172 (Dec. 15, 1988).
Newkirk, M.M. et al., "Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family" J. Clin. Invest. 81:1511-1518 (May 1988).
O'Connor, M. et al., "Construction of large DNA segments in E. coli" Science 244:1307-1312 (Jun. 16, 1989).
Ogino, M. et al., "Affinity Studies of Human Anti-MAG Antibodies in Neuropathy" J. Neuroimmunol. 52:41-46 (1994).
Ott, D.E. et al., "Immunoglobulin Heavy Chain Switch Region Recombination Within a Retroviral Vector in Murine Pre-B Cells" EMBO J. 6(3):577-587 (1987).
Ott, D.E. and Marcu, K.B., "Molecular Requirements for Immunoglobulin Heavy Chain Constant Region Switch-Recombination Revealed with Switch-Substrate Retroviruses" Intl. Immunol. 1(6):582-591 (1989).
Pascual, V. et al., "The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis" J. clni, Invest. 86:1320-1328 (Oct. 1990).
pedersen, L. et al., "An Approach for Characterization and Purification of a Human Monoclonal Hybridoma Antibody" Hybridoma 8(1):97-105 (1989).
Petersen, V.B. et al., "A Human-Mouse Hybridoma which Secretes Monoclonal Thyroglobulin Autoantibody w
Kay Robert M.
Lonberg Nils
GenPharm International Inc.
Ziska Suzanne E.
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