Transgenic mouse model of B cell malignancy

Details Transgenic mouse model of B cell malignancy Transgenic mouse model of B cell malignancy

2007-04-24

2010-02-23

Wilson, Michael C. (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S003000, C800S021000

Reexamination Certificate

active

07667090

ABSTRACT:
A transgenic non-human animal, such as a mouse, has a genome that include a nucleic acid construct having at least one transcriptional regulatory sequence capable of directing expression in B cells of the animal, wherein the transcriptional regulatory sequence is operably linked to a nucleic acid encoding a miR155 gene product. A method of testing the therapeutic efficacy of an agent in treating or preventing a lymphoproliferative condition includes assessing the effect(s) of the agent on a transgenic non-human animal.

REFERENCES:
Bichi (PNAS, May 14, 2002, vol. 99, No. 10, p. 6955-6960).
Eis (PNAS, Mar. 8, 2005, vol. 102, No. 10, p. 3627-3632).
PCT/US2007/009910 International Preliminary Report on Patentability dated Nov. 6, 2008.
PCT/US2007/009910 Search Report and Written Opinion dated Feb. 13, 2008.
Bichi et al., Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression, PNAS, 2002, vol. 99, No. 10, pp. 6955-6960.

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