Transgenic mouse model for pituitary disorders associated with L

Details Transgenic mouse model for pituitary disorders associated with L Transgenic mouse model for pituitary disorders associated with L

1996-05-09

1998-10-20

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 435 691, 435 695, 4353201, 435325, 424 921, 536 235, 536 2351, C12N 500, C12N 1500, C12N 1509

Patent

active

058248382

ABSTRACT:
Recombinant transgenic mice expressing leukemia inhibitory factor (LIF) in the pituitary. The transgenic mice of the invention are suitable for use as animal models of pituitary disorders, as well as for identifying compounds which stimulate growth hormone production, for the treatment of physiological disorders associated with growth retardation and pituitary developmental retardation disorders, such as chraneopharyngioma, and pituitary cysts, among others.

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