Transgenic mouse model for neurodegenerative diseases

Details Transgenic mouse model for neurodegenerative diseases Transgenic mouse model for neurodegenerative diseases

2008-07-01

2008-07-01

Falk, Anne-Marie (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal in an in vivo...

C800S018000

Reexamination Certificate

active

09933640

ABSTRACT:
Alzheimer's disease, Parkinson's disease and Lewy body disease are the most commonly found neurodegenerative disorders in the elderly. The invention is a transgenic mouse that contains two transgenes, human α-synuclein and human amyloid precursor protein, which are responsible for the formation of the neuritic plaques, Lewy bodies and neurodegeneration seen in the above mentioned diseases. The transgenic mouse is an accurate model for disease by both functional and pathological assays.

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