Transgenic mouse lacking PAPP-A activity

Details Transgenic mouse lacking PAPP-A activity Transgenic mouse lacking PAPP-A activity

2007-05-22

2007-05-22

Bertoglio, Valarie (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S013000, C800S014000

Reexamination Certificate

active

10499472

ABSTRACT:
The invention provides materials and methods related to a transgenic non-human mammal whose genome comprises a disrupted PAPP-A allele. Methods for making such transgenic non-human mammals, and using them identify and characterize agents that affect conditions related to PAPP-A activity, such as vascular restenosis, atherosclerosis, wound healing, cancer, fibrosis, bone development, fetal development, longevity, and fracture repair, also are provided.

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