Transgenic mouse for the neuronal expression of HIV gp160

Details Transgenic mouse for the neuronal expression of HIV gp160 Transgenic mouse for the neuronal expression of HIV gp160

1994-06-06

1996-10-29

Ziska, Suzanne E.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351223, 536 231, 800DIG1, 800DIG4, C12N 1500, C07H 2102

Patent

active

055698271

ABSTRACT:
The present invention relates to a transgenic non-human mammal, whose germ cells and somatic cells contain a recombinant env gene sequence which is operably linked to a promoter effective for the expression of the gene in the neuronal tissues of the mammal and effective for the simulation of neurological syndromes associated with HIV-1, the gene being introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammal is such that transcription of the env gene may be under the control of a promoter sequence, such as a neuron specific promoter of human neurofilament light gene (NFL). The promoter can be synthetic or inducible. The transgenic non-human mammal can be a rodent, such as a mouse.

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