Transgenic mouse for the neuronal expression of HIV gp160

Details Transgenic mouse for the neuronal expression of HIV gp160 Transgenic mouse for the neuronal expression of HIV gp160

1996-07-24

1998-12-15

Ziska, Suzanne E.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 536 231, 800DIG1, 800DIG4, C12N 1500, C07H 2102

Patent

active

058500014

ABSTRACT:
The present invention relates to a transgenic non-human mammal, whose germ cells and somatic cells contain a recombinant env gene sequence which is operably linked to a promoter effective for the expression of the gene in the neuronal tissues of the mammal and effective for the simulation of neurological syndromes associated with HIV-1, the gene being introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammal is such that transcription of the env gene may be under the control of a promoter sequence, such as a neuron specific promoter of human neurofilament heavy gene (NFH). The promoter can be synthetic or inducible. The transgenic non-human mammal can be a rodent, such as a mouse.

REFERENCES:
patent: 5569827 (1996-10-01), Kessous-Elbaz
Berrada, F. et al., 1995, J. Virol., 69:6770-6778.
Brenneman, D.E. et al., 1988, Nature (London), 335:639-642.
Budka, H., 1990 a), In: Chopra J, Jagannathan K, Sawhney IMS (eds) Advances in Neurology. Excerpta Medica, Amsterdam, 193-202.
Budka, H., 1990 b), Acta Neuropathol., 79:611-619.
Budka, H. et al., 1991, Brain Pathol., 1:143-152.
Cheng-Mayer, C. et al., 1987, Proc. Natl. Acad. Sci. USA, 84:3526-3530.
Dreyer, E.B. et al., 1990, Science, 248:364-367.
Epstein, L.G. et al., 1993, Ann. Neurol., 33:429-436.
Epstein, L.G. et al., 1986, Pediatrics, 78:678-687.
Gyorkey, F. et al., 1987, J. Infect. Diseases, 155:870-876.
Janssen, R.S., 1991, Neurology, 778:773-785.
Julien, J.P. et al., 1987, Genes & Development, 1:1085-1095.
Ketzler, S. et al., 1990, Acta neuropathol. (Berl), 80:92-94.
Koenig, S. et al., 1986, Science, 233:1089-1093.
Lee, M.R. et al., 1987, Science, 237:1047-1051.
Levy, J.A. et al., 1985, Lancet, ii:586-588.
Lipton, S., 1991, Brain Pathology, 1:193-199.
Lipton, S.A., 1992, Trends Neurosci., 15:76-80.
Masliah, E. et al., 1992, Lab. Investigation, 66:285-291.
Navia, B.A. et al., 1986 b), Ann. Neurol., 19:525-535.
Navia, B.A. et al., 1986 a), Ann. Neurol., 19:517-524.
Price, R.W. et al., 1988, Science, 239:586-592.
Pulliam, L. et al., 1993, AIDS Res Hum Retroviruses, 9:439-444.
Savio, T. et al., 1993, J. Neurosc. Res., 34:265-272.
Shen, Y.M. et al., 1982, Mol. Cell. Biol., 2:1145-1154.
Stoler, M.H. et al., 1986, JAMA, 256:2360-2364.
Sweetnam, P.M. et al., 1993, Eur. J. Neurosc., 5:276-283.
Vazeux, R. et al., 1987, American J. Pathol., 126:403-410.
Villa, G. et al., 1993, J Neur Neurosurgery Psy, 56:878-884.
Weis, S. et al., 1993, Acta Neuropathol, 85:185-189.
Wigdahl, B. et al., 1989, AIDS Res. Hum. Retroviruses, 5:369-374.
Wiley, C.A. et al., 1986, Proc. Natl. Acad. Sci. USA, 83:7086-7093.

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