Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1994-01-14
1997-05-20
Stone, Jacqueline M.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
4351723, 424 91, C12N 500, C12N 1500, C12P 1500, A61K 4900
Patent
active
056314078
ABSTRACT:
The subject invention provides an isolated nucleic acid molecule which comprises nucleic acid encoding a polypeptide which has the biological activity of a receptor for poliovirus and in addition, provides a purified polypeptide which has this activity. The subject invention also provides a method for inducing the production of a polypeptides which includes the use of expression vectors in a host vector system. Therapeutic compositions comprising purified polypeptides which have the biological activity of a receptor for poliovirus are also provided for as are methods of treating and preventing human poliovirus infection. Further, the subject invention provides a method of producing a transgenic animal expressing human poliovirus receptors. The subject invention provides a method of testing the efficacy of a poliovirus receptors vaccine which comprises administering the vaccine to a transgenic animal described above and determining whether the resulting transgenic animal is protected from infection by human picornavirus. Lastly, a method of testing the virulence of a picornavirus vaccine is provided.
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Costantini Frank
Mendelsohn Cathy
Racaniello Vincent
Chan Albert Wai-Kit
Crouch Deborah
Stone Jacqueline M.
The Trustees of Columbia University in the City of New York
White John P.
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