Transgenic mouse expressing C-100 app

Details Transgenic mouse expressing C-100 app Transgenic mouse expressing C-100 app

1996-02-26

1999-04-13

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 424 92, 4353201, C12N 500, C12N 1500

Patent

active

058940782

ABSTRACT:
A transgenic mouse whose genome comprises a DNA sequence encoding the carboxy-terminal 100 amino acids of the human .beta.-amyloid precursor protein C-100 APP) inserted into exon I of the neurofilament gene such that all or part of exon I has been deleted is disclosed. Expression of the nucleic acid sequence is under the control of neurofilament L-gene regulatory region. The mouse as a result of the expression exhibits a brain morphology of an increased amyloid accumulation, and increase in reactive astrocytes, an increased microglial activation and a decreased number of neurons, and also exhibits spatial memory impairment.

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