Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1994-11-14
2000-03-14
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 9, 800 12, 800 3, 424 91, 424 92, A01K 6700, A01K 67027
Patent
active
060375213
ABSTRACT:
The invention relates to an animal model of human Alzheimer's disease that is useful for determining the mechanism of the disease and for developing and testing potential therapeutic drugs. More particularly, the present invention relates to the creation of transgenic non-human mammalian animals having integrated into their genome an exogenous DNA construct that encodes a portion of a .beta.-amyloid precursor protein ("APP") and that is designed to overexpress in various types of animal tissues.
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Kawarabayashi Takeshi
Kobayashi Takashi
Sato Masahiro
Shoji Mikio
Tada Norihiro
Crouch Deborah
Hoechst Japan Limited
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