Transgenic mouse deficient in T-cells

Details Transgenic mouse deficient in T-cells Transgenic mouse deficient in T-cells

1995-11-16

1998-12-08

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 435 691, 435 696, 435694, 435 912, 4353201, 536 231, 536 235, 536 2431, 935 23, 935 78, 935 79, 935 70, 935 71, C12N 500, C12N 1500, C12N 1509

Patent

active

058472576

ABSTRACT:
The present invention relates to a transgenic mouse deficient in T-cells, which is provided by fusing human heat shock protein (Hsp) gene with H2K promoter and transferring it to a mouse. Transgenic mouse line with a shrunken thymus and edficient in T-cells not having mature T-cells can be obtained.

REFERENCES:
patent: 5087571 (1992-02-01), Leder et al.
patent: 5175383 (1992-12-01), Leder et al.
patent: 5175384 (1992-12-01), Krimpenfort et al.
patent: 5175385 (1992-12-01), Wagner
Morello et al., The EMBO Journal, vol. 5, pp. 1877-1883, 1986.
Hunt et al., Proclamation of the National Academy of Science, USA, vol. 82, pp. 6455-6459, 1985.
Uney et al., Society for Neuroscience Abstracts, vol. 18, p. 1145, 1992.

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