Transgenic mouse deficient in inducible nitric oxide synthase

Details Transgenic mouse deficient in inducible nitric oxide synthase Transgenic mouse deficient in inducible nitric oxide synthase

1997-02-28

1998-12-15

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 4351723, 4353201, 424 92, C12N 500, C12N 1500, A61K 4900

Patent

active

058500049

ABSTRACT:
The present invention provides an inducible nitric oxide synthase ("iNOS")-deficient transgenic mouse, novel replacement vectors designed for the disruption of the iNOS gene, embryonic stem (ES) cells which are singly allelic relative to the deficient iNOS locus, a host cell line or cell clone carrying a congenitally altered iNOS gene, and a method of producing such a transgenic mouse.
The iNOS-deficient transgenic mice can be used to evaluate and/or test their susceptibility to infectious or tumorigenic challenge, autoimmunity, septic shock and inflammatory and allergic diseases.

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