Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2009-03-27
2011-12-13
Bertoglio, Valarie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S008000, C800S009000, C800S010000, C800S003000, C424S009200
Reexamination Certificate
active
08076532
ABSTRACT:
Mechanisms regulating cell proliferation stop and differentiation initiation during the development stage of mammalian embryo, and the proteins involved therein, are presented. Differentiation regulators, methods of regulating differentiation, transgenic organisms with loss of expression of the differentiation regulator, and methods of preparing the transgenic organisms, are provided.
REFERENCES:
Denning and Priddle, 2003, Reproduction, 126:1-11.
Smith, Jour Biotechnolo, 2002, 99:1-22.
Rami L. Aqeilan et al., “WW Domain-Cintaining Proteins, WWOX and YAP, compete for Interaction with ErbB-4 and Modulate Its Transcriptional Function”, Cancer Research vol. 65 pp. 6764-6772 (Aug. 1, 2005).
Qi Zeng et al., “The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals”, Cancer Cell vol. 13 pp. 188-192 (Mar. 11, 2008).
Joo-Hyeon Lee, et al., A crucial role of WW45 in developing epithelial tissues in the mouse, The EMBO Journal, (2008) 27, 1231-1242.
Kim Jin-Man
Kim Tae-Shin
Kong Young-Yun
Koo Bon-Kyoung
Lee Joo-Hyeon
Bertoglio Valarie
Korea Advanced Institute of Science and Technology
Lexyoume IP Group, PLLC.
LandOfFree
Transgenic mouse defective in WW45 function and use in... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transgenic mouse defective in WW45 function and use in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic mouse defective in WW45 function and use in... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4266810