Transgenic mouse cells expressing ts SV40 large T

Details Transgenic mouse cells expressing ts SV40 large T Transgenic mouse cells expressing ts SV40 large T

1993-02-11

1997-11-18

Crouch, Deborah

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Rodent cell, per se

435325, 435377, 435 691, 800 2, C12N 500, C12N 1500, C12P 2106

Patent

active

056886926

ABSTRACT:
The provision of cell lines from virtually any cell type of the animal body is greatly facilitated by transgenic non-human eukaryotic animals of the invention in which at least some cells have (i) a differentiation inhibiting sequence chromosomally incorporated under the control of a non-constitutive promotor and/or (ii) a differentiation inhibiting sequence which is itself conditionally active. Said genes are chromosomally incorporated under the control of a promotor such that expression of said sequence is normally held below an effective level, thus allowing normal cell development. However, cells taken from said animal may be prevented from completing differentiation to a non-dividing state in tissue culture by activating expression of said sequence.

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