Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1995-02-15
1998-03-03
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG2, 424 92, C12N 500, C12N 1500, A61K 4900
Patent
active
057237190
ABSTRACT:
The present invention provides a transgenic mouse which exhibits a circling phenotype as a result of insertional mutagenesis. The insertional mutant was caused by introducing genetic material into the genome of the mouse, or an ancestor thereof, at an embryonic stage. The genetic material appears to alter or disrupt an endogenous genetic locus affecting motor function, resulting in the mutation. More particularly, transgenic mouse lines were made by microinjection of about 24 kb XhoI genomic DNA fragment containing the mouse Ren-2.sup.d renin gene into BCF.sub.1, fertilized eggs. One transgenic mouse line, designated TgX15 (also known as chakragati mice), bred to homozygosity was found to exhibit a circling phenotype. The transgenic mouse line TgX15 may be an important resource for investigating the molecular genetic mechanisms that determine specific aspects of brain function and behavior. Also, these mice may be useful to evaluate new and potentially more effective agents for the therapeutic treatment of disorders involving dopaminergic dysfunction such as Parkinsonism and schizophrenia.
Fitzgerald Lawrence W.
Glick Stanley D.
Gross Kenneth W.
Mullins John J.
Ratty Anil K.
Crouch Deborah
Health Research , Inc.
LandOfFree
Transgenic mouse as model for diseases involving dopaminergic dy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transgenic mouse as model for diseases involving dopaminergic dy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic mouse as model for diseases involving dopaminergic dy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2250075