Transgenic mice with disrupted NPY Y1 receptor genes

Details Transgenic mice with disrupted NPY Y1 receptor genes Transgenic mice with disrupted NPY Y1 receptor genes

1997-01-16

1998-10-06

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 800DIG2, 424 92, 4351723, 4353201, 435354, C12N 500, C12N 1500, A61K 4900

Patent

active

058179127

ABSTRACT:
The present invention is directed to transgenic animals which have been engineered by homologous recombination to be deficient in the expression of the neuropeptide Y Y1 receptor. The invention encompasses the DNA constructs and engineered embryonic stem cells used to produce the animals, the transgenic animals themselves, and assays which utilize either the animals or tissues derived from the animals.

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