Transgenic mice which overexpress neurotrophin-3 (NT-3) and meth

Details Transgenic mice which overexpress neurotrophin-3 (NT-3) and meth Transgenic mice which overexpress neurotrophin-3 (NT-3) and meth

1995-11-27

1999-01-12

Stanton, Brian R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

424 91, 424 92, 4351723, 536 231, 536 2351, 536 241, A61K 4900, C12N 518, C12N 1509, C12N 1518

Patent

active

058593110

ABSTRACT:
Transgenic mice express increased levels of neurotrophin-3 (NT-3) in epithelium when their ancestors are microinjected with the NT-3 gene. The NT-3 growth factor expressing transgenic mice are useful in the study of neurodegenerative disorders of the brain such as Parkinson's syndrome and Alzheimer's disease, of the spinal cord motor neurons such as amyotrophic lateral sclerosis, and for testing drug candidates for the treatment of these diseases.

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