Transgenic mice which overexpress nerve growth factor

Details Transgenic mice which overexpress nerve growth factor Transgenic mice which overexpress nerve growth factor

1995-05-08

1997-02-11

Stanton, Brian R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 800DIG1, 800DIG4, C12N 1500, C12P 2100, A01K 6700

Patent

active

056023090

ABSTRACT:
Transgenic mice that express increased levels of nerve growth factor (NGF) in the epidermis and other stratified, keratinized epithelium. The nerve growth factor expressing transgenic mice are useful in the study of neurodegenerative disorders of the brain such as Parkinson's syndrome and Alzheimer's disease and for testing for drug candidates for the treatment of these diseases.

REFERENCES:
patent: 4185095 (1980-01-01), Young
patent: 4736866 (1988-04-01), Leder et al.
patent: 5082774 (1992-01-01), Heinrich
patent: 5175383 (1992-12-01), Leder et al.
patent: 5175384 (1992-12-01), Krimpenfort et al.
patent: 5175385 (1992-12-01), Wagner et al.
patent: 5180820 (1993-01-01), Barde et al.
patent: 5231001 (1993-07-01), Kaplan et al.
Vassar, Robert, et al. "Tissue-specific and differentiation-specific expression of human K14 keratin gene in transgenic mice", Proc. Natl. Acad. Sci. USA, vol. 86, (Mar. 1989) pp. 1563-1567.
Edwards, Robert H., et al. "Directed Expression of NGF to Pancreatic .beta. Cells in Transgenic Mice Leads to Selective Hyperinnervation of the Islets", Cell, vol. 58, (Jul. 14, 1989) pp. 161-170.
Patil, Nila, et al. "Specific Neuronal Expression of Human NGF Receptors in the Basal Forebrain and Cerebellum of Transgenic Mice", Neuron, vol. 2, (Mar. 1990) pp. 437-447.
Vassar, Robert et al. "Transgenic Mice Provide New Insights into the Role of TGF-.alpha. During Epidermal Development and Differentiation", Genes & Development, vol. 5, (1991) pp. 714-727.
Borrelli, Emiliana, et al. "Pituitary Hyperplasia Induced by Ectopic Expression of Nerve Growth Factor", Proc. Natl. Acad. Sci. USA, vol. 89, (Apr. 1992) pp. 2764-2768.
Ard, M. D., Morest, D. K. (1984). Intl. J. Dev. Neurosci. 2, 535-547.
Oppenheim, R. W. (1991). Ann. Rev. Neurosci. 14, 453-501.
Thoenen, H. and Barde, Y. A. (1980). Physiol. Rev. 60, 1284-1334.
Oppenheim, R. W. (1989). Trends in Neurosci. 12, 252-255.
Davies, A. M., Larmet, Y., Wright, E., Vogel, K. S. (1991). J. Cell Sci. 15, 111-116.
Oppenheim, R. W. (1981). Studies in Developmental Biology (ed. W. M. Cowan) pp. 74-133. Oxford University Press.
Cowan, W. M. Fawcett, J. W., O'Leary, D. D. M., and Stanfield, B. B. (1984). Science 225, 1258-1265.
Levi-Montalcini, R. and Booker B. (1960). Proc. Natl. Acad. Sci. U.S.A 46, 384-391.
Hefti, F. (1986) J. Neurosci. 6, 2155-2161.
Williams, L. R., Varon, S., Peterson, G., Wictorin, K., Fischer, W., Bjorklund, A. & Gage, F. H. (1986). Proc. Natl. Acad. Sci. U.S.A. 83, 9231-9235.
Johnson, E. M., Gorin, P. D., Brandeis, L. D., Pearson, J. (1980). Science 210, 916-918.
Barde, Y. A., Edgar, D., Thoenen H. (1980). Proc. Natl. Acad. Sci. U.S.A. 77, (1980) 1199-1203.
Hamburger, V. and Yip, H. W. (1984). J. Neurosci. 4, 767-774.
Davies, A. M., Bandtlow, D., Heumann, R., Korsching, S., Rohrer, H., and Thoenen, H. (1987) Nature 326, 353-358).
Rohrer, H., Heumann, R., Thoenen, H. (1988). Dev. Biol. 128, 240-244.
Harper, S. J., and Davies, A. M. (1990). Development 110, 515-519.
Schweizer, J., and Winter, H. (1982) Differentiation 22, 19-24.
Kopan, R. and Fuchs, E. (1989) Genes and Devel. 3, 1-15.
Edwards et al. 1989 Cell 58: 161-170.
Davies et al. 1987. Nature 326: 353-358.
Vassar et al. 1989. Proc. Nat'l Acad. Sci., USA 86: 1563-1567.
Sandgren et al. 1990. Cell 61: 1121-1135.
Soppet et al. 1991. Cell 65: 895-903.
Khillan et al. 1986. Proc. Nat'l. Acad. Sci, USA. 83: 725-729.

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